Diagnostically significant changes in subsets CD11b<sup>+</sup>CD64<sup>-</sup>CD32<sup>+</sup>CD16<sup>+</sup>, CD11b<sup>+</sup>CD64<sup>+</sup>CD32<sup>+</sup>CD16<sup>+</sup> neutrophilic granulocytes of immunocompromised women with chronic infectious and inflammatory diseases of the genital tract of various etiologies

Chronic pelvic inflammatory disease (PID) in women remains a problem due to the importance of medical consequences. The study receptor apparatus neutrophilic granulocytes (NG) involved anti-infective protection diseases various etiologies seems be relevant. Aim: clarify features variants quantitative and phenotypic changes subsets NG CD11b + CD64 - CD32 CD16 , immunocompromised during exacerbation chronic PID etiologies. We were tested 20-40 years: Study Group 1 (SG1, n = 20) – with mono- or mixed latent/recurrent viral infections (chronic herpes-virus infections, papillomavirus infection, recurrent ARVI); 2 (SG2, 30) bacterial etiologies; Comparison (CG)– 20 healthy women. number (major) (minor), expression density (MFI) was determined (FC500, USA). It found that period exacerbation, diagnostically significant differences subset composition revealed. got decrease СD64 СD32 СD16 7,6 times increase SG2 etiology, contrast occurring combination recurrent/persistent infection SG1. Negative transformation is associated predominant level activation CD16. absence an adequate response infectious process revealed major SG1, as well minor groups SG1 SG2. In marker CD11b. (SG1), negatively altered we CD16, CD32. Determination their phenotype can used diagnostic markers for differential diagnosis development new methods targeted immunomodulatory therapy.